Mehul T Dattani Selected Research

Hypopituitarism (Sheehan's Syndrome)

1/2021	Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans.
12/2020	Development of the Pituitary Gland.
1/2020	Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism.
1/2020	Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome.
12/2019	Mutations in MAGEL2 and L1CAM Are Associated With Congenital Hypopituitarism and Arthrogryposis.
4/2019	Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation.
12/2015	Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD).
10/2013	ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies.
7/2011	Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.
4/2011	Increased transactivation associated with SOX3 polyalanine tract deletion in a patient with hypopituitarism.

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Mehul T Dattani Research Topics

Disease

20	Hypopituitarism (Sheehan's Syndrome) 01/2021 - 10/2003
10	Hypothyroidism 01/2022 - 12/2003
9	Combined Pituitary Hormone Deficiency 01/2020 - 01/2004
9	Pituitary Dwarfism 06/2015 - 01/2004
8	Septo-Optic Dysplasia 12/2020 - 12/2003
8	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2017 - 11/2003
4	Diabetes Insipidus 12/2019 - 09/2009
3	Neoplasms (Cancer) 01/2022 - 07/2011
3	Delayed Puberty 05/2019 - 12/2006
3	Morbid Obesity 01/2017 - 11/2003
3	Adrenal Insufficiency (Adrenal Gland Hypofunction) 02/2012 - 11/2003
3	Obesity 01/2007 - 05/2003
2	Growth Disorders 01/2020 - 05/2006
2	Congenital Abnormalities (Deformity) 01/2020 - 10/2013
2	Congenital Hypothyroidism (Cretinism) 12/2018 - 12/2015
2	Hypoparathyroidism 01/2017 - 01/2015
2	Kallmann Syndrome (Kallmann's Syndrome) 09/2015 - 10/2011
2	Seizures (Absence Seizure) 01/2015 - 10/2013
2	Insulin Resistance 04/2014 - 10/2009
2	Craniopharyngioma (Craniopharyngiomas) 08/2012 - 07/2011
2	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 02/2012 - 05/2003
2	Intellectual Disability (Idiocy) 04/2011 - 01/2007
2	Anophthalmos (Anophthalmia) 05/2008 - 01/2007
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2022
1	Prolactinoma (Prolactinomas) 01/2022
1	Multiple Endocrine Neoplasia Type 1 01/2022
1	Primary Hyperparathyroidism 01/2022
1	Primary Ovarian Insufficiency 01/2022
1	Legg-Calve-Perthes Disease (Perthes Disease) 01/2021
1	Hip Dislocation 01/2021
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2020
1	Pierson syndrome 01/2020
1	Pituitary Diseases (Disease, Anterior Pituitary) 12/2019
1	Adducted Thumbs) Syndrome Shuffling Gait Aphasia MASA (Mental Retardation 12/2019
1	Arthrogryposis 12/2019
1	Hydrocephalus (Hydrocephaly) 12/2019
1	Schaaf-Yang syndrome 12/2019
1	Sleep Apnea Syndromes (Sleep Apnea) 12/2019
1	Megalencephaly 12/2019
1	Cardiomyopathies (Cardiomyopathy) 05/2019
1	MEHMO syndrome 04/2019
1	Eczema 01/2018
1	Endodermal Sinus Tumor (Endodermal Sinus Tumors) 02/2017
1	Cushing Syndrome 02/2017
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2017
1	Thyroid Diseases (Thyroid Disease) 01/2017
1	Adenoma (Adenomas) 01/2017
1	Diabetes Mellitus 01/2017
1	Hirsutism 01/2017
1	Precocious Puberty 01/2017
1	Pituitary ACTH Hypersecretion 07/2016
1	Hypertension (High Blood Pressure) 07/2016
1	Anosmia 09/2015
1	Laurence-Moon Syndrome (Syndrome, Laurence-Moon) 02/2015
1	Chromosome Aberrations (Chromosome Abnormalities) 02/2014
1	Substance-Related Disorders (Drug Abuse) 02/2014
1	Chronic Disease (Chronic Diseases) 02/2014

Drug/Important Bio-Agent (IBA)

19	Hormones (Hormone)IBA 01/2021 - 12/2003
13	Transcription Factors (Transcription Factor)IBA 12/2015 - 07/2005
12	Growth Hormone (Somatotropin)IBA 01/2022 - 01/2004
6	Adrenocorticotropic Hormone (ACTH)FDA Link 12/2019 - 03/2005
5	Insulin (Novolin)FDA Link 01/2017 - 05/2003
5	Gonadotropin-Releasing Hormone (GnRH)FDA Link 09/2015 - 03/2009
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2011
4	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2020 - 05/2003
3	Pituitary HormonesIBA 01/2020 - 05/2008
3	ProlactinIBA 12/2012 - 08/2005
3	polyalanineIBA 04/2011 - 05/2005
3	SOXB1 Transcription FactorsIBA 10/2010 - 01/2007
2	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2022 - 09/2009
2	GonadotropinsIBA 02/2014 - 12/2006
2	Biomarkers (Surrogate Marker)IBA 02/2013 - 08/2012
2	CateninsIBA 08/2012 - 07/2011
2	GlucocorticoidsIBA 02/2012 - 02/2007
2	somatotropin releasing hormone receptorIBA 09/2011 - 10/2010
2	Alanine (L-Alanine)FDA Link 04/2011 - 05/2005
2	Human Growth Hormone (Saizen)FDA LinkGeneric 10/2010 - 05/2006
2	EnzymesIBA 03/2007 - 11/2003
2	SaltsIBA 02/2007 - 05/2003
1	6-methyladenineIBA 01/2022
1	Laminin (Merosin)IBA 01/2020
1	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)IBA 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 04/2019
1	Letrozole (Femara)FDA LinkGeneric 01/2019
1	Immunoglobulin E (IgE)IBA 01/2018
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 02/2017
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2016
1	LuciferasesIBA 12/2015
1	neurotoxic esteraseIBA 02/2015
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2015
1	Calcium-Sensing ReceptorsIBA 01/2015
1	CreatinineIBA 01/2015
1	CalciumIBA 01/2015
1	Parathyroid Hormone (Parathormone)IBA 01/2015
1	Blood Glucose (Blood Sugar)IBA 04/2014
1	LipidsIBA 04/2014
1	Gonadal Steroid Hormones (Sex Hormones)IBA 02/2014

Therapy/Procedure

4	Therapeutics 05/2019 - 05/2006
1	Parathyroidectomy 01/2022
1	Investigational Therapies (Experimental Therapy) 01/2017